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  • Alpha-1 & COPD
    • Alpha-1 Pathophysiology
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  • Screening
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Order Free AlphaID Test Kits
  • Alpha-1 Pathophysiology
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AAT deficiency is not rare; it is rarely diagnosed

Find out more about the estimated prevalence of AAT deficiency

Benefits of increasing detection and early diagnosis of AAT deficiency

Discover what the benefits of an early diagnosis of AAT deficiency are.

Benefits of increasing detection and early diagnosis of AAT deficiency

Discover what the benefits of an early diagnosis of AAT deficiency are.

About AlphaID™ Screening Test

AlphaID cheek swab is a genetic test that screens for the 14 most prevalent mutations associated with alpha-1 antitrypsin (AAT) deficiency.

About AlphaID™ Screening Test

AlphaID cheek swab is a genetic test that screens for the 14 most prevalent mutations associated with alpha-1 antitrypsin (AAT) deficiency.

Advocacy & Professional Organizations

Useful links to the major clinical organizations and foundations for further information and support about alpha-1 antitrypsin (AAT) deficiency and COPD.

Alpha-1 Patient Types

Watch this video to learn why genetic screening for alpha-1 in all patients with COPD is recommended, regardless of age, smoking history, or FEV1.

Alpha-1 Patient Types

Watch this video to learn why genetic screening for alpha-1 in all patients with COPD is recommended, regardless of age, smoking history, or FEV1.

Support for Practices that Screen with AlphaID

The role of respiratory therapists, nurse practitioners and physician assistants in alpha-1 antitrypsin (AAT) deficiency diagnosis.

Consequences of AAT Deficiency

The most common mortality cause in patients with AAT deficiency is respiratory failure.

Consequences of AAT Deficiency

The most common mortality cause in patients with AAT deficiency is respiratory failure.

AAT Deficiency Diagnosis

Alpha-1 antitrypsin (AAT) deficiency shares signs and symptoms with COPD (which includes emphysema, asthma and chronic bronchitis). Individuals may wait 8 years to get diagnosed.

How to Screen with AlphaID™

Watch a demo video on how to screen for alpha1-antitrypsin (AAT) deficiency with AlphaID™, the fast, easy, and accurate cheek swab that is provided compliments of Grifols and may not be billed to patients or their insurers.

How to Screen with AlphaID™

Watch a demo video on how to screen for alpha1-antitrypsin (AAT) deficiency with AlphaID™, the fast, easy, and accurate cheek swab that is provided compliments of Grifols and may not be billed to patients or their insurers.

AlphaID™ Screening Test Fit into my Practice

Diagnosing alpha-1 antitrypsin (AAT) deficiency has evolved to become relatively simple, in two steps; screening test and diagnosis test.

AAT Deficiency FAQs

Frequently asked questions about alpha-1 antitrypsin deficiency, its connection with COPD, disease diagnosis, screening guidelines and more.

Order AlphaID™ Test Kits

Order form to request free AlphaID™ genetic screening test kits for alpha-1 antitrypsin (AAT) deficiency.

Order AlphaID™ Test Kits

Order form to request free AlphaID™ genetic screening test kits for alpha-1 antitrypsin (AAT) deficiency.

Alpha-1 Antitrypsin Deficiency and COPD

Alpha-1 is the #1 genetic risk for COPD. AAT deficiency is a contributing cause in approximately 3% of COPD cases in the US.

Deficient AAT alleles

Of more than 900,000 COPD patients screened for alpha-1 over 10 years, 15% (>140,000 patients) had at least 1 deficient allele

Deficient AAT alleles

Of more than 900,000 COPD patients screened for alpha-1 over 10 years, 15% (>140,000 patients) had at least 1 deficient allele

Why Screen for Alpha-1

Watch to learn why screening for alpha-1 is important. Approximately 90% of patients with alpha-1, also known as genetic COPD, are estimated to be undiagnosed.

Why Screen for Alpha-1

Watch to learn why screening for alpha-1 is important. Approximately 90% of patients with alpha-1, also known as genetic COPD, are estimated to be undiagnosed.

AAT Deficiency Resources

Curated collection of alpha-1 antitrypsin (AAT) deficiency videos and downloads for healthcare professionals.

AAT Deficiency Inheritance Pattern

The most common genotypes, AAT serum levels, and risk for AAT deficiency. See alpha-1 family tree and learn how is alpha-1 inherited

AAT Deficiency Screening Guidelines

Alpha-1 antitrypsin (AAT) deficiency testing guidelines from COPD Foundation, ATS, GOLD, WHO and CHEST.

Pathophysiology of AAT Deficiency

Causes of alpha-1 antitrypsin (AAT) deficiency and the disordered physiological processes associated with this genetic form of COPD.

AlphaID™ Contact Info

Contact us for more information about AlphaID™ screening test and alpha-1 antitrypsin deficiency.

'Alpha ID' logo
  • Alpha-1 & COPD
    • Alpha-1 Pathophysiology
    • Alpha-1 Inheritance Pattern
  • Screening
    • Diagnostic Journey
    • HCP Practice Support
  • AlphaID Screening Test
    • Testing Overview
    • Order AlphaID Test Kits
  • Resources
    • Videos and Downloads
    • Advocacy Organizations
    • FAQs
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