~90% of patients with alpha-1 are undiagnosed2,3

Alpha1-antitrypsin (AAT) deficiency, also known as alpha-1 or genetic COPD, is one of the world's most prevalent, potentially fatal hereditary diseases.3,4
Alpha-1 may be a contributing cause for up to 3% of all COPD cases in the United States.1,3

Learn more about alpha-1 >

Home screening

Screening for alpha-1 is free,* fast, and easy with AlphaID

AlphaID is a fast and easy cheek swab that screens for alpha-1.5 Ruling out alpha-1 as a contributing cause of COPD has never been easier.

Order free AlphaID kits now >

Home Leading

Leading clinical organizations recommend screening all patients with COPD for alpha-16-10

Screening of all patients with COPD for alpha-1, regardless of age and smoking history, is recommended by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) and the World Health Organization (WHO), as well as the following organizations

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American Thoracic Society (ATS)

American College of Chest Physicians

COPD Foundation

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*AlphaID is completely free, provided compliments of Grifols, and may not be billed to patients or their insurers.

Home references

COPD, chronic obstructive pulmonary disease.

  1. Alpha-1 Foundation. Lung disease. https://www.alpha1.org/Newly-Diagnosed/Learning-about-Alpha-1/Lung-Disease. Accessed October 28, 2019.
  2. Alpha-1 Foundation. Look into genetic COPD. https://www.alpha1.org/Alphas-Friends-Family/Resources/News/ArtMID/5952/ArticleID/7792/Grifols-launches-educational-campaign-Look-into-Genetic-COPD. Published February 28, 2018. Accessed November 4, 2019.
  3. Campos MA, Wanner A, Zhang G, Sandhaus RA. Trends in the diagnosis of symptomatic patients with α1-antitrypsin deficiency between 1968 and 2003. J Clin Invest. 1999;104(3):337-344.
  4. Campbell EJ, Campbell MA, Boukedes SS, Owen CA. Quantum proteolysis by neutrophils: implications for pulmonary emphysema in α1-antitrypsin deficiency. J Clin Invest. 1999;104(3):337-344.
  5. A1AT Genotyping Test Package Insert. Progenika Biopharma.
  6. Global Initiative for Chronic Obstructive Lung Disease. Pocket guide to COPD diagnosis, management, and prevention. https://goldcopd.org/wp-content/uploads/2018/11/GOLD-2019-POCKET-GUIDE-DRAFT-v1.7-14Nov2018-WMS.pdf. Accessed November 7, 2019.
  7. World Health Organization. α1-antitrypsin deficiency: memorandum from a WHO meeting. Bull World Health Organ. 1997;75(5):397-415.
  8. American Thoracic Society/European Respiratory Society. American Thoracic Society/European Respiratory Society statement: standards for the diagnosis and management of individuals with alpha-1 antitrypsin deficiency. Am J Respir Crit Care Med. 2003;168(7):818-900.
  9. CHEST Foundation. Learn about alpha-1 antitrypsin deficiency. https://foundation.chestnet.org/patient-education-resources/alpha-1-antitrypsin-deficiency/. Accessed November 3, 2019.
  10. Sandhaus RA, Turino G, Brantly ML, et al. The diagnosis and management of alpha-1 antitrypsin deficiency in the adult. Chronic Obstr Pulm Dis. 2016;3(3):668-682.